Understanding Selective Androgen Receptor Modulators (SARMs)
When it comes to bodybuilding and fitness, Selective Androgen Receptor Modulators (SARMs) have gained popularity for their ability to provide the anabolic benefits of testosterone without the same harmful side effects. Originally designed to help cancer patients with muscle wasting, SARMs work by signaling specific tissues in the body, particularly muscle and bone, to grow. However, these synthetic drugs are not limited to cancer patients; they are also used by regular individuals who want to improve their physical appearance.
Traditional anabolic steroids, when they bind to androgen receptors in the body, not only promote muscle growth but also affect other tissues that contain these receptors. This is why these drugs often come with unwanted side effects that many users try to avoid. SARMs, on the other hand, are designed to selectively target specific tissues, minimizing side effects. While they work similarly to testosterone, they are not as effective. Nonetheless, their selectivity allows them to have strong anabolic effects in muscle and bone while using a smaller dose compared to anabolic steroids.
Benefits of SARMs
The selectivity of SARMs offers two main benefits. Firstly, they can provide powerful anabolic effects in the targeted tissues. Secondly, these effects can be achieved with lower doses compared to anabolic steroids. This means that lingering side effects are minimized, making SARMs highly advantageous for muscle growth and physical performance improvement.
How SARMs Work
Selective androgen receptor modulators (SARMs) focus on the androgen receptors found in muscle tissues while reducing activity in other parts of the body. By doing so, they accelerate desired anabolic results such as increased muscle mass, improved physical endurance, and stronger bones. What sets SARMs apart is their ability to potentially alleviate or even prevent the usual side effects associated with non-specific androgenic steroids, such as benign prostatic hyperplasia, male pattern baldness, severe acne, gynecomastia, aggression, mood disturbances, and suppression of natural testosterone production. This ability to counteract these effects has sparked significant interest in SARMs.
Types of SARMs
Among the various SARMs that have been studied for potential medical use, there are a few that have become particularly popular among bodybuilders and physique athletes due to their remarkable muscle- and strength-building effects. These include:
1. Ostarine (MK-2866): Ostarine is one of the most extensively studied SARMs known for its ability to increase muscle mass and maintain muscle strength. It is also used to combat muscle depletion caused by injuries, tumors, multiple sclerosis (MS), and other conditions. Additionally, researchers are exploring whether ostarine can help fight against osteoporosis and sarcopenia. In the fitness and bodybuilding community, daily doses of 12.5mg-25mg are commonly used.
2. Ligandrol (LGD-4033): Originally developed to prevent muscle wasting diseases, Ligandrol has gained attention for its ability to promote dense, high-quality muscle growth, enhance strength, and accelerate fat loss. Despite being classified as a SARM, its anabolic potential surpasses that of many conventional steroids. Bodybuilders typically take doses ranging from 5mg to 20mg daily.
3. Testolone (RAD-140): Testolone has shown the highest muscle-building potential among all the SARMs currently under research. Initially studied as a potential male contraceptive pill, Testolone’s ability to boost protein synthesis and nitrogen retention leads to significant lean mass and strength gains, comparable to powerful anabolic agents like Trenbolone. Recommended doses for bodybuilding fall within the range of 10 to 20mg daily.
Risks of Using SARMs
While SARMs offer promising benefits, their use also poses potential risks to human health. The full extent of their impact on various body systems is still unknown. Some potential risks associated with SARMs include reduced production of endogenous testosterone and impaired Hypothalamic-Pituitary-Testicular Axis function, negative effects on cholesterol and lipid profiles, liver toxicity (especially when taken orally), and vision problems such as abnormal color perception or sensitivity to light. Masculinizing effects, such as increased body hair growth, deepening of the voice, and menstrual cycle disruptions, are common in women who use SARMs.
Legality and Regulation of SARMs
The legality and regulation of SARMs are complex issues. SARMs have not been approved by the FDA for human consumption, and they are not labeled or packaged for human use. They are considered investigational compounds. In Canada, their sale and distribution for purposes not covered by existing laws are not in the best interest of the general public and are not therapeutically necessary.
It is crucial to approach the use of SARMs with caution and under the supervision of trained medical professionals who can assess the benefits and risks. Using them without proper guidance can have serious side effects. Self-medication with these substances is not comparable to steroid use because it eliminates the level of medical supervision necessary. This only increases the risks involved.